FAQ: What is the difference between “N6” and “m6A” nomenclature?

m6A refers to N6-methyladenosine, which is an RNA modification where a methyl group is attached to the N6 position of the adenine base. mRNA Cap N6 Methyltransferase (m6A) methylates the initiating adenine (+1 A) of 5´-capped RNA transcripts to create m6A at the cap-proximal position.