HomeFAQsWhen I dissolve the lyophilized product, the solution at first appears turbid. Is this normal?
FAQ: When I dissolve the lyophilized product, the solution at first appears turbid. Is this normal?
Yes, this is normal. The lyophilized cake in vial format dissolves immediately, but the release of air from the cake results in a temporary increase turbidity. The air will naturally degas from solution over ~20 seconds or after gentle vortexing. In the 96-well plate-based format, gentle mixing or vortexing results in immediate dissolution of the cake.
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